Excellence Journal of Medical Science http://ejmedic.org/index.php/ejhcs <p>Excellence Journal of Medical Science is an Open Access International Journal, which intends to connect and inform doctors, researchers and other health professionals by publishing a broad range of peer-reviewed articles. Our background is solidly grounded in publishing a high degree of articles covering all aspects of medicine.</p> <p>ISSN - 1858-943X</p> Elsheikh Abdalla Elbadri university – excellence research center- Dar ALtamayoz en-US Excellence Journal of Medical Science 1858-943X <p><strong>Copyright</strong>: By submitting a manuscript the, the authors agree that the copyright is transfer toElsheikh<strong> Abdallah Elbadri University – Excellence Research Center - Excellence Journal of Medical Sciences.</strong></p> <p><strong>e-mail: </strong><a href="mailto:erc@eaeu.edu.sd"><strong>erc@eaeu.edu.sd</strong></a></p> Constituents and Antimicrobial Activity of Sudanese Azadirachta indica (Meliaceae) Fixed Oil http://ejmedic.org/index.php/ejhcs/article/view/3 <p>In this study Azadirachta indica fruit oil was studied by GC-MS. The oil was also assessed for antimicrobial activity. The GC-MS analysis revealed the presence of 29 constituents .The major constituents of the oil are: i) 9-octadecenoic acid methyl ester (37.20%) , ii) methyl stearate(20.42%) , iii) hexadecanoic acid methyl ester(19.13%) and iv) 9, 12-octadecadienoic acid methyl ester (12.60%).The antimicrobial activity of the oil was evaluated via the agar diffusion bioassay against five standard pathogenic bacteria (Gram positive: Staphylococcus aureus and Bacillus subtilis; Gram negative: Esherichia coli, Pseudomonasaaeruginosa) and the fungus Candida albicans. At a concentration of 100mg/ml the oil showed good activity against Escherichia coli. However, at the same concentration, it exhibited partial activity against Staphylococcus aureus and Bacillus subtilis. The oil failed to give any anticandidal activity.</p> Abdel Karim, M AbdelAzim, I Um-Alahasan,T Copyright (c) 2020 Excellence Journal of Medical Science 2020-01-02 2020-01-02 1 1 16 23 Effect of direct exposure to ringing mobile phone waves on ECG heart rate and rhythm among healthy adults http://ejmedic.org/index.php/ejhcs/article/view/4 <p>The effect of electromagnetic wave from mobile phones on human health is of great interest, the current study was designed to investigate the effect of mobile phone electromagnetic waves on ECG heart rate and rhythm among different healthy adult volunteers’ ages and sex while mobile phone was placed on the chest pocket level during ringing mode. It was an experimental, comparative study conducted in the period from march 2014 to August 2016 in north of Sudan at Elsheikh Abdallah Elbadri University among 850 volunteers, Sudanese and other nationalities.500 male and 350 females, aged 16 - 49 years were included in the study. ECG was done before and after exposure to ringing mobile phone. Significant changes in ECG heart rate and rhythm was detected and the results was found to be consistent in males and females’ group. The study conclude that mobile phone is not a safety device and should not be used by medical staff inside the ECG rooms.</p> Ishraga. A Ibrahim Eman Zeen Elabdeen Hashim Yassin Omer A Elbedri Samia H Abdalwahab Maria A Aboelhassan Alwathig Y Mohamed Copyright (c) 2020 Excellence Journal of Medical Science 2020-01-02 2020-01-02 1 1 33 37 Phytochemical Screening and Antifungal Activity of Faidherbia albida Roots http://ejmedic.org/index.php/ejhcs/article/view/5 <p>Faidherbia albida Dell. (Mimosodceae), locally known as alharaz. All plant parts have an important role in traditional medicine except for the root part. The study aims to quantify the alkaloids in the Faidherbia albida root chloroform extract and to assess the antifungal activity of the roots chloroform extract against three pathogenic fungi: Aspergillus fusarium, Aspergillus fulvus, and Candida albicans. The primary phytochemical analysis of chloroform extract showed the presence of alkaloids, diterpenes and flavonoids, Saponins and phytosterols, but glycosides were not detected. The yield percentage of the raw maceration extract is 3.8%. In thin-layer chromatography (TLC), it revealed the detection of one compound under U V light as light blue spots (RF 0.833). The total alkaloid content in the chloroform roots extract was 121.142mg AE/g, while the total phenol content is 53.960mg GAE/g. The extract at concentration 200mg/ml revealed no inhibition effect against all microorganisms tested except Candida albicans (17mm). This study found that Faidherbia albida contains a high concentration of alkaloids compared with the other plant parts and moderate phenol content compared with the leaves part, as well as anticandidal activity against both the standard and isolated strain tested.</p> Esraa E K Abdurrahman Mona A M Mageed Copyright (c) 2020 Excellence Journal of Medical Science 2020-01-02 2020-01-02 1 1 38 43 Photochemical Analysis, Antioxidant Activity and Cytotoxicity of Adansonia digitata L. Seeds Ethanol Extract http://ejmedic.org/index.php/ejhcs/article/view/6 <p>Adansonia digitate Linn (Malvaceae) is a native plant to the west Sudan, locally named Tabaldy. Adansonia digitate seeds are believed to have nutritional and medicinal benefits in Sudan. The aims of this study are to screening the phytochemicals of Adansonia digitate L seeds ethanol extract and to assess the antioxidant activity and cytotoxicity. The phytochemical screening revealed the presence of glycosides, saponins, steroids, flavonoids, and protein, but alkaloids, tannins and resins were not detected. The antioxidant test of baobab seeds ethanol extract was performed by using the DPPH scavenging test which revealed a moderate activity (53.04±0.067) with IC50 value 0.092± 0.006. The cytotoxicity was tested using three cancer cell line: lung cancer cell (A549), breast cancer cell (MCF7), hepatic cancer cell (HEPG2) and tow normal cell line melanocytes cell (HFB4) and fibrinocytes cell (BHK). The cytotoxicity result of the seed aqueous ethanol extract was exhibited a cytotoxic effect against the normal cell tested (HFB4), (BHK) with IC50 11.6, and 24.5 μg/ml respectively and no effect on cancer cell tested except (MCF7) cell with IC50 11.5 μg/ml. This study does not support the use of seeds powder as nutrition due to the cytotoxic effect.</p> Mona A M Mageed Huiam Salah Eldeen IzzEldeen AbdAlaziz Copyright (c) 2020 Excellence Journal of Medical Science 2020-01-02 2020-01-02 1 1 24 32 The Effect of Solvents to Extract Phenol and Phenol Related Compounds Contents and Some Biological Screening of Salvia officinalis http://ejmedic.org/index.php/ejhcs/article/view/7 <p>Saliva officinalis (Lamiaceae) herbal plant collected from Khartoum local market. This study has three aims, to assess the efficacy of three aqueous organic solvents to extract the phenol and phenol derivative metabolites using the maceration method, to assess the antifungal and anticancer of Saliva officinalis aqueous extracts using Yeast – Based bioassay against three mutant yeast strains Saccharomyces cerevisiae, and to assess the antioxidant activity of Saliva officinalis extracts using two methods: DPPH radical scavenging assay, and TLC Autography technique. The results revealed that the 70% methanol has high total phenols (318.35mg GAE/g) and total flavonoids (189.38mg QE/g) while the 70% acetone extract was revealed high total tannin content (218.34 mg TAE/g). The 70% acetone extract revealed activity against the three mutant yeast tested with inhibition zone diameter more than 12 mm at concentration 5mg/ml and 10mg/ml respectively. While the other extracts were exhibited no activity against the three mutant strains tested. All extracts were reflected anti-Candida activity and the maximum IZD was exhibited by the 70%ethanol extract (30mm). All extracts were free-radical inhibitors but 70% methanol extract was more potent (0.068mg/ml) than the other extracts.</p> Mona A M Abdelmageed Copyright (c) 2020 Excellence Journal of Medical Science 2020-01-02 2020-01-02 1 1 7 15 Assessment of respiratory muscles power and lung function tests in asthmatics, police women trainees and healthy obese adults in Khartoum state (2010-2013) http://ejmedic.org/index.php/ejhcs/article/view/8 <p>Asthma is one of the main respiratory health problems worldwide. Asthma diagnosis when moderate or severe is easy depending on wheezing &amp; other symptoms, but mild and intermittent asthma could be a clinical challenge. Respiratory muscles power is indirectly measured through mouth pressures (maximal inspiratory pressure [MIP] and maximal expiratory pressure [MEP] ).Lung function and respiratory muscles power were measured in: 35 asthmatics before and after bronchodilators and 20 non asthmatic controls; 30 normal subjects and 15 asthmatics at 6:00 a.m and 6:00 p.m; 28 trained policewomen athletes and 31 matched untrained controls; 52 healthy obese subjects with body mass index (BMI) ≥ 30kg/m2 and 43 matched non obese subjects (BMI &lt; 25kg/ m2). Significant increase in FVC, FEV1, PEFR, MEP and MIP were observed after bronchodilator test in asthmatics, at 6:00 p.m, in trained subjects compared to that obtained before bronchodilator test, at 6:00 a.m, in untrained subjects respectively. MEP and MIP significantly increased in obese compared to non-obese subjects with MEP is positively correlated with weight and % fat is negatively correlated to FVC and FEV1.Insignificant difference was detected in lung function between obese and non-obese subjects. The study concluded that respiratory muscles power (MEP and MIP) reversibility and variability testing could be potential sensitive tests in diagnosis of asthma and respiratory muscles power could be also a sensitive tool for assessment of athletes, performance. The normal lung function in obese subjects could be due to improved respiratory muscle power in them.</p> Omer A Musa Omer Abdalla Elbedri Abdalla Copyright (c) 2020 Excellence Journal of Medical Science 2020-01-02 2020-01-02 1 1 1 7